GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12464559 | 1 | rs12464559 | chr2:152597660 | ARL5A | chr2:152645593-152685009:- | -0.24 | -4 | 6.88E-5 | Response to cognitive-behavioural therapy in anxiety disorder |
| BRCA | cis | rs4146922 | 1 | rs12464737 | chr2:56029838 | EFEMP1 | chr2:56093103-56150932:- | -0.18 | -4.53 | 6.51E-6 | Height |
| BRCA | cis | rs950880 | 1 | rs12470864 | chr2:102926362 | IL18R1 | chr2:102927962-103015215:+ | 0.11 | 4.91 | 1.03E-6 | Serum protein levels (sST2) |
| BRCA | cis | rs4638749 | 1 | rs12472278 | chr2:108873433 | SULT1C2 | chr2:108905095-108926370:+ | -0.29 | -7.04 | 3.54E-12 | Blood pressure |
| BRCA | cis | rs7589728 | 1 | rs12473740 | chr2:88527647 | THNSL2 | chr2:88469835-88486145:+ | -0.67 | -12.88 | 2.12E-35 | Plasma clusterin levels |
| BRCA | cis | rs4671458 | 1 | rs12473894 | chr2:63376570 | C2orf86 | chr2:63348537-63815851:- | -0.2 | -4.93 | 9.53E-7 | Subjective well-being |
| BRCA | cis | rs6722750 | 1 | rs12475563 | chr2:64384515 | C2orf86 | chr2:63348537-63815851:- | -0.12 | -3.77 | 0.000173 | Neuroticism |
| BRCA | cis | rs6722750 | 1 | rs12475563 | chr2:64384515 | CEP68 | chr2:65283495-65314141:+ | -0.11 | -3.53 | 0.000431 | Neuroticism |
| BRCA | cis | rs7608623 | 1 | rs12478744 | chr2:23947589 | LOC375190 | chr2:24299728-24397519:+ | 0.2 | 5.99 | 2.83E-9 | Obesity-related traits |
| BRCA | cis | rs950880 | 1 | rs12479210 | chr2:102949161 | IL18R1 | chr2:102927962-103015215:+ | 0.11 | 4.75 | 2.29E-6 | Serum protein levels (sST2) |
| BRCA | cis | rs6087771 | 1 | rs12479491 | chr20:30265450 | COX4I2 | chr20:30225691-30232800:+ | 0.18 | 6.72 | 2.91E-11 | Subcortical brain region volumes |
| BRCA | cis | rs6087771 | 1 | rs12479491 | chr20:30265450 | MYLK2 | chr20:30407178-30422500:+ | 0.31 | 8.11 | 1.36E-15 | Subcortical brain region volumes |
| BRCA | cis | rs59374417 | 1 | rs12487080 | chr3:119294482 | CD80 | chr3:119243142-119278481:- | 0.12 | 4 | 6.88E-5 | Vitiligo |
| BRCA | cis | rs59374417 | 1 | rs12487334 | chr3:119291419 | CD80 | chr3:119243142-119278481:- | 0.12 | 4 | 6.88E-5 | Vitiligo |
| BRCA | cis | rs59374417 | 1 | rs12487335 | chr3:119291425 | CD80 | chr3:119243142-119278481:- | 0.12 | 4 | 6.88E-5 | Vitiligo |